e-Library of Evidence for Nutrition Actions (eLENA)


An online library of evidence-informed guidelines for nutrition interventions and single point of reference for the latest nutrition guidelines, recommendations and related information.

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Vitamin D supplementation and respiratory infections in children

Intervention | Last updated: 9 August 2023


Vitamin D is known to play an important role in bone metabolism through regulation of calcium and phosphate homeostasis and may also play an important role in immune system regulation. Vitamin D is produced by the body during exposure to sunlight, but is also found in oily fish, eggs and fortified food products.

In addition to causing rickets, vitamin D deficiency has been linked to respiratory infections such as pneumonia, tuberculosis and bronchiolitis. Pneumonia is a severe form of acute lower respiratory tract infection and is the leading cause of death in children worldwide.

Some studies have suggested that vitamin D supplementation can decrease the frequency and severity of respiratory infections among children, however further research is needed before specific recommendations can be made.

WHO Recommendations


Further research is needed before specific recommendations can be made.

Guidelines and guidance documents Learn More Alternate Text


GRC-approved guidelines


Status: Not currently available

Evidence


Related Cochrane reviews


Vitamin D supplementation for preventing infections in children under five years of age

Yakoob MY, Salam RA, Khan FR, Bhutta ZA. Cochrane Database of Systematic Reviews. 2016; Issue 11. Art. No.: CD008824.

Summary of this review Alternate Text

Other related systematic reviews


Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis

Charan J, Goyal JP, Saxena D, Yadav P. Journal of Pharmacology and Pharmacotherapeutics. 2012; 3:300-3.


Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Bergman P, Lindh AU, Björkhem-Bergman L, Lindh JD. PLoS One. 2013; 8:e65835.


Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P et al. BMJ. 2017;356:i6583.


Cost-effectiveness Learn More Alternate Text


Relevant cost-effectiveness analyses have not yet been identified.